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Paper #81760 Citation Details:

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Authors: Goswami, H., Sengupta, P., & Chandra, AK.
Title: Calcium and magnesium mediated modulation of thyroid status by hypothalamo-pituitary-thyroid axis.
Journal: Physicon2011
Volume: 1
Issue:
Start Page: 115
End Page: 116
Year: 2011
Web Link:
Abstract: Background: Recent advancements and growing health awareness have rendered human being to expose excess calcium and magnesium from natural as well as anthropogenic sources. Hypothesis: Epidemiological studies reported from our laboratory showed hard water (containing relatively high calcium and magnesium) responsible for etiopathogenesis of endemic goiter, suggesting these as modulator of thyroid function through hypothalamo-pituitary-thyroidal axis. An approach to get insight into this intricate mechanistic aspect is the objective of this study. Materials and Methods: Adult male albino rats (Wistar strain) were subjected to of calcium (CaCl2) and magnesium (MgSO4) exposure at selected doses for different durations and a comparative assessment was made by the assay of TSH, T3 and T4 followed by thyroidal parameters as thyroid gland weight, its histoarchitecture along with TPO, Na+-K+-ATPase, DI activities. Results: The results showed that both calcium and magnesium altered thyroid gland weight thyroid histoarchitecture associated with thyroid hormone synthesizing enzymes namely Na+-K+-ATPase activities, TPO activities and thyroid hormone profiles (TSH, T3 and T4). Discussion: Calcium and magnesium modulate hypothalamo-pituitary-thyroid axis evidenced by thyroid hormone profiles (T4, T3 and TSH) along with the activities of TPO, Na+-K+-ATPase and DI. The overall results indicate prolonged exposure to calcium and magnesium at relatively high doses renders the animals to thyroid disruption. This study reaffirms our earlier epidemiological findings of potent deleterious effects of excess calcium and magnesium on thyroid status challenging the recent trend of indiscriminate use of them, especially in the form of supplements.

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