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Paper #81757 Citation Details:

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Authors: Sengupta, P., Sarkar, M., & Chandra, AK.
Title: Comparative Study of Calcium and Magnesium Induced Oxidative Stress Leading to Gonadal Impairment in Male Rats.
Journal: National Symposium on "Frontiers in Modern Biology" organized by Department of Biological Sciences,
Volume: 1
Start Page: 18
End Page: 0
Year: 2011
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Abstract: Active oxygen causes various problems including male infertility through the oxidation of DNA, proteins, and lipids. Calcium has shown in some experiments to cause chemical sterilization in different animals, but evidence of the involvement of a similar mechanism(s) in magnesium-induced testicular dysfunction is scarce. The present investigation has been conducted to explicate the effect of excess dietary calcium and magnesium-induced oxidative damages and thus testicular impairment in investigational model. To conduct the study, adult male albino rats (around 90days old) were fed with calcium and magnesium salts in excess at different doses for a single spermatogenic cycle and chemosterilizing and stress-persuading effect of these salts were estimated by using parameters like weights of sex organs, sperm count, serum testosterone and LH & FSH levels, testicular and adrenal ?5 3ß-HSD & testicular 17ß-HSD activity and testicular histopathology, lipid peroxidation, catalase, SOD, serum corticosterone was measured. A significant alteration (P<0.05) has observed in both cases after treatment.

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