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Paper #81756 Citation Details:

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Authors: Sengupta, P., Sarkar, M., & Chandra, AK.
Title: Excess Dietary Calcium Depresses Male Gonadal Activity by Inducing Oxidative Stress in Adult Albino Rats.
Journal: 98th Indian Science Congress
Volume: 1
Start Page: 193
End Page: 0
Year: 2011
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Abstract: Despite reactive oxygen species (ROS) are important for normal functioning of various cells, but can interrupt common physiological pathways and cause cell death at oxidative stress levels. They are also vital mediators of testicular physiology and pathophysiology. Calcium which has been accounted in various reports to cause chemocastration has been taken to conduct the study to explicate the effect of excess dietary calcium-induced oxidative damages in male reproductive system in investigational model. To carry out the same, adult male wister strain rats (90days of age) were fed with CaCl2 for different doses for their two and four spermatogenic cycles. Anti-gonadal and stress-inducing effect of calcium was estimated by using parameters like relative weights of testicular and accessory sex organs, epididymal sperm count, serum testosterone and LH & FSH levels, steroidogenic enzymes activities (testicular and adrenal ?5 3ß-Hydroxy Steroid Dehydrogenase & testicular 17ß-Hydroxy Steroid Dehydrogenase) and testicular histoarchitecture, testicular lipid peroxidation, catalase, SOD, serum corticosterone was measured. A significant alteration (P<0.05) has observed after calcium treatment describing calcium causes oxidative stress induced altered adrenocortical activity that relates to hypogonadism in experimental rats.

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