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Paper #81755 Citation Details:

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Authors: Sengupta, P., Sarkar, M., & Chandra, AK.
Title: Effect of Consumption of Excess Hard Water Salts on Male Gonadal Status in Adult Albino Rats.
Journal: National Conference by Dept of Human Physiology with Community Health, Vidyasagar University
Volume: 1
Start Page: 277
End Page: 0
Year: 2010
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Abstract: Background & Objectives: Global epidemiological studies reported a correlation between consumption of hard water (excess calcium and magnesium salts) and its adverse effect on different physiological systems. This investigation has been undertaken to evaluate the effect of two prime hard water salts (Calcium Chloride and Magnesium Sulfate) on male reproductive system in experimental model. Methods: To conduct the study adult male Wister strain rats (90days of age) were fed with CaCl2 and MgSO4 at doses 1.0 gm and 1.5 gm % per day for 60 days. Anti-gonadal effect of these salts was estimated using the parameters like relative testicular weight, relative weight of accessory sex organs, epididymal sperm count, serum testosterone level, testicular steroidogenic enzymes activities (?5 3ß-Hydroxy Steroid Dehydrogenase & 17ß-Hydroxy Steroid Dehydrogenase) and testicular histoarchitechture. Results: Significant reduction in testicular and accessory sex organs weights, along with inhibition of ?5 3ß-HSD & 17ß-HSD activity and diminution in serum testosterone level, were observed in both the doses of CaCl2. The degree of inhibition in all the parameters was increased dose-dependently. But in case of MgSO4 treated rats significant increase in the activities of steroidogenic enzyme activities was found in the dose of 1.5gm % per day, but no such alteration was noticed in dose of 1.0gm % per day. Interpretation and Conclusion: All these findings establish that long term consumption of calcium salt produces suppressive effect on testicular status mainly on testicular weight, accessory sex organ weight and steroidogenesis in dose-dependant manner, whereas magnesium treatment showed positive association with male gonadal system in high dose.

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